Voodoo Lab

Just got the new PX-8 plus and psyched to get my pedalboard setup!! Could use some tips to optimize.

Current setup (without PX-8 switcher):
Into front of my Mesa Boogie Mark V 25 - Wireless line 6 Relay > Morley volume/wah combo > polytune3 > mesa amp channel switcher > Mesa Flux Drive > Fender Pugilist Distortion
Into effects loop - Strymon timeline. Also just got Julia chorus/vibrato and was thinking about running it through effects loop as well (could run through front of amp if better).

Planning to run PX-8 with preset method.:
*Not sure what the optimum chain/sequence would be. Thinking of just going straight 1-8 and putting wireless, volume, tuner in front of the input--unless there's a better way for those three.
*For the timeline, I would love to take advantage of the MIDI function to assign specific types of delays to a few of the presets if possible. Not sure if I need to add control switcher for that.

Any help would be greatly appreciated. Thanks!